Trifluoroacetic Acid Catalyzed Cascade Reactions of 2,3‐Diketoesters with Cyclohexane‐1,3‐diones: Strategy Towards 4‐Hydroxybenzofuran Derivatives | Zendy

Sha Qiang | Zendy; Liu Haixuan | Zendy; Li Yuan | Zendy

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Trifluoroacetic Acid Catalyzed Cascade Reactions of 2,3‐Diketoesters with Cyclohexane‐1,3‐diones: Strategy Towards 4‐Hydroxybenzofuran Derivatives

Author(s) -

Sha Qiang,

Liu Haixuan,

Li Yuan

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900056

Subject(s) - chemistry , trifluoroacetic acid , cyclohexane , cascade , catalysis , derivatization , combinatorial chemistry , cascade reaction , organic chemistry , functional group , chromatography , polymer , high performance liquid chromatography

An efficient trifluoroacetic acid catalyzed cascade reaction of 2,3‐diketoesters with cyclohexane‐1,3‐diones is described for the synthesis of a series of 4‐hydroxybenzofurans. This simple protocol has the advantages of easy operation, readily available starting materials, good functional group tolerance, and easily scale‐up. Subsequent derivatization of the 4‐hydroxybenzofurans provides a reasonable route to access highly functionalized benzofurans.

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