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Catalytic Asymmetric Cyanation Reactions of Aldehydes and Ketones in Total Synthesis
Author(s) -
Zeng XingPing,
Sun JunChao,
Liu Chao,
Ji CongBin,
Peng YiYuan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900015
Subject(s) - cyanation , chemistry , synthon , enantioselective synthesis , catalysis , organic chemistry , optically active , total synthesis , combinatorial chemistry
Catalytic asymmetric cyanation reactions of aldehydes and ketones provide efficient routes for the synthesis of optically active cyanohydrins, which are versatile synthons for the preparation of natural products and chemical pharmaceuticals. This review aims to provide a summary of recent achievements concerning catalytic enantioselective cyanation reactions of aldehydes and ketones employed in the total syntheses of various natural products, drugs, and pharmaceutically active compounds.