Premium
Ligand‐free Palladium‐Catalyzed Carbonylative Suzuki Coupling of Aryl Iodides in Aqueous CH 3 CN with Sub‐stoichiometric Amount of Mo(CO) 6 as CO Source
Author(s) -
Sun Nan,
Sun Qingxia,
Zhao Wei,
Jin Liqun,
Hu Baoxiang,
Shen Zhenlu,
Hu Xinquan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900011
Subject(s) - chemistry , palladium , aryl , catalysis , stoichiometry , reagent , suzuki reaction , aqueous solution , carbonylation , ligand (biochemistry) , inorganic chemistry , organic chemistry , carbon monoxide , biochemistry , alkyl , receptor
A new method for the synthesis of diaryl and heterodiaryl ketones has been established based on the palladium‐catalyzed carbonylative Suzuki coupling approach with sub‐stoichiometric Mo(CO) 6 as CO source. Using 0.5 mol% of Pd(TFA) 2 as catalyst, 0.5 equivalent of Mo(CO) 6 as solid carbonyl reagent and 3 equivalent of K 3 PO 4 as base, a wide range of functionalized (hetero)aryl iodides and (hetero)aryl boronic acids could smoothly proceed the carbonylative cross‐coupling reaction in aqueous CH 3 CN at 50 °C, affording the corresponding ketones in good to excellent yields. The newly developed method was easy to operate under mild conditions with high efficiency.