Premium
A Tf 2 O‐Promoted Synthesis of Functionalized Quinolines from Ketoximes and Alkynes
Author(s) -
Zheng Weiping,
Yang Weiguang,
Luo Dongping,
Min Lin,
Wang Xinyan,
Hu Yuefei
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801724
Subject(s) - chemistry , beckmann rearrangement , combinatorial chemistry , in situ , organic chemistry , medicinal chemistry , catalysis
A new general synthesis of quinolines was developed from ketoximes and alkynes in the presence of Tf 2 O. It offered the first direct synthesis of quinolines by using the nitrilium salts generated in situ from a Tf 2 O‐promoted Beckmann rearrangement of ketoximes under very easy conditions.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom