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Copper‐Catalyzed Sequential C( sp 2 )/C( sp 3 )−H Amination of 2‐Vinylanilines with N ‐Fluorobenzenesulfonimide
Author(s) -
Cao WenBin,
Xu XiaoPing,
Ji ShunJun
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801710
Subject(s) - chemistry , amination , catalysis , intermolecular force , nitrogen , copper , substrate (aquarium) , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule , oceanography , geology
Abstract An oxidative C−H diamination of 2‐vinylanilines with N ‐fluorobenzenesulfonimide (NFSI) was developed for the efficient synthesis of indole frameworks. The reaction proceeded via sequential intra‐/intermolecular diamination of C( sp 2 )−H and C( sp 3 )−H bond, incorporating one nitrogen from the substrate and the other nitrogen from the NFSI.