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Chiral Anion‐Induced Catalytic Asymmetric Direct Dehydrative Coupling of 3‐Vinylindoles and 3‐Indolylmethanols
Author(s) -
Li XiaoYun,
Hu WeiTing,
Xiong QiuJu,
Ye SiMin,
Huang YanMin,
Guo QiXiang
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801705
Subject(s) - chemistry , catalysis , indole test , brønsted–lowry acid–base theory , alkene , combinatorial chemistry , alcohol , coupling (piping) , direct coupling , ion , medicinal chemistry , stereochemistry , organic chemistry , mechanical engineering , electrical engineering , engineering
The catalytic direct dehydrative coupling of an alkene with an alcohol is one of the most straightforward and green strategies for the formation of C sp 2 −C sp 2 bonds. However, previously reported studies have only dealt with achiral reactions. Here, we describe chiral Brønsted acid‐catalyzed direct catalytic asymmetric dehydrative coupling reactions of 3‐vinylindoles and 3‐indolylmethanols. Various structurally diverse indole compounds were prepared in good to excellent yields, with good to excellent stereoselectivities.