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Photoredox‐Catalzyed Halo‐trifluoromethylation of 1,7‐Enynes for Synthesis of 3,4‐Dihydroquinolin‐2(1 H )‐ones
Author(s) -
Yuan Xin,
Zheng MingWei,
Di ZheChen,
Cui YuSheng,
Zhuang KaiQiang,
Qin LongZhou,
Fang Zheng,
Qiu JiangKai,
Li Guigen,
Guo Kai
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801681
Subject(s) - trifluoromethylation , chemistry , halo , combinatorial chemistry , halogen , photoredox catalysis , photocatalysis , reaction conditions , catalysis , photochemistry , organic chemistry , trifluoromethyl , alkyl , physics , quantum mechanics , galaxy
An efficient photoredox‐catalyzed halo‐trifluoromethylation reaction of 1,7‐enynes has been developed under mild conditions. This photocatalytic protocol provides an efficient and functional strategy leading to CF 3 − and halogen‐containing 3,4‐dihydroquinolin‐2(1 H )‐ones from a wide range of 1,7‐enynes through two different radical pathways. The reaction mechanism was proposed based on the control experiments.