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Oxidative N‐Heterocyclic Carbene‐Catalyzed [8+2] Annulation of Tropone and Aldehydes: Synthesis of Cycloheptatriene‐Fused Furanones
Author(s) -
Xia Fei,
Gao ZhongHua,
Zhang ChunLin,
Ye Song
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801679
Subject(s) - tropone , cycloheptatriene , chemistry , annulation , cyclooctane , carbene , catalysis , cycloheptane , medicinal chemistry , organic chemistry , ring (chemistry)
The N‐heterocyclic carbene catalyzed [8+2] oxidative annulation of tropone with aldehydes was developed, giving cycloheptatriene‐fused furanones in moderate to good yields. Further reduction of the cycloadducts afforded cycloheptane‐fused furanones and dihydrofuranones in good yields.