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The Employment of Sodium Hydride as a Michael Donor in Palladium‐catalyzed Reductions of α, β‐Unsaturated Carbonyl Compounds
Author(s) -
Liu Ye,
Mao Yujian,
Hu Yanwei,
Gui Jingjing,
Wang Liang,
Wang Wei,
Zhang Shilei
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801676
Subject(s) - chemistry , hydride , catalysis , michael reaction , conjugate , sodium hydride , palladium , molecule , cascade , sodium , atom economy , organic chemistry , combinatorial chemistry , medicinal chemistry , hydrogen , mathematical analysis , mathematics , chromatography
Sodium hydride was employed as a Michael donor under the catalysis of PdCl 2 for 1,4‐conjugate reductions of α, β‐unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom‐economy. The merits of NaH as a reductant were demonstrated by the one‐pot or cascade reactions for the syntheses of complex molecules.