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Cs 2 CO 3 ‐Mediated Vicinal Thiosulfonylation of 1,1‐Dibromo‐1‐Alkenes with Thiosulfonates: An Expedient Synthesis of ( E )‐1,2‐Thiosulfonylethenes
Author(s) -
Reddy Raju Jannapu,
Kumari Arram Haritha,
Kumar Jangam Jagadesh,
Nanubolu Jagadeesh Babu
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801620
Subject(s) - vicinal , chemistry , aryl , transformation (genetics) , caesium , combinatorial chemistry , carbonate , metal , organic chemistry , alkyl , biochemistry , gene
Abstract A new and highly efficient vicinal thiosulfonylation of 1,1‐dibromo‐1‐alkenes with thiosulfonates in the presence of cesium carbonate has been developed. The metal‐free diheterofunctionalization is an operationally simple to access a wide range of ( E )‐1,2‐thiosulfonylethenes (α‐aryl‐β‐thioarylvinyl sulfones) in moderate to high yields with high levels of stereoselectivities. Further, scalable reactions have been demonstrated for this transformation, thus illustrating its efficiency and practicality.