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A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α‐Halocarboxylic Acids
Author(s) -
Monticelli Serena,
Urban Ernst,
Langer Thierry,
Holzer Wolfgang,
Pace Vittorio
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801614
Subject(s) - chemistry , magnesium , halogen , carbon dioxide , enantiopure drug , sulfoxide , flexibility (engineering) , organic chemistry , scope (computer science) , carbenoid , carbon fibers , catalysis , enantioselective synthesis , rhodium , alkyl , statistics , mathematics , computer science , programming language , materials science , composite number , composite material
The homologation of carbon dioxide with stable, (enantiopure) magnesium carbenoids constitutes a valuable method for preparing α‐halo acid derivatives. The tactic features a high level of chemocontrol, thus enabling the synthesis of variously functionalized analogues. The flexibility to generate magnesium carbenoids through sulfoxide‐, halogen‐ or proton‐ Mg exchange accounts for the wide scope of the reaction.