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Rhodium(III)‐catalyzed Intermolecular Unactivated Secondary C( sp 3 )−H Bond Amidation Directed by 3,5‐dimethylpyrazole
Author(s) -
Wang Yanwei,
Liu Hongxin,
Li Bin,
Wang Baiquan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801592
Subject(s) - chemistry , nitrene , intermolecular force , intramolecular force , catalysis , rhodium , substrate (aquarium) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , molecule , oceanography , geology
A Rh(III)‐catalyzed intermolecular unactivated secondary C( sp 3 )−H bond amidation via nitrene insertion directed by 3,5‐dimethylpyrazole is reported. This procedure tolerates a broad substrate scope including chain and cyclic N‐alklyamides. Notably, the directing group 3,5‐dimethylpyrazole of chain N‐alkylamide substrates could be easily removed via cascade intermolecular amidation and intramolecular cyclization in one‐pot affording the sulfonylureas by increasing the reaction temperature.