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Flavin‐Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination
Author(s) -
Ismail Mohamed,
Frese Marcel,
Patschkowski Thomas,
Ortseifen Vera,
Niehaus Karsten,
Sewald Norbert
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801591
Subject(s) - chemistry , xanthomonas campestris , halogenation , halogen , regioselectivity , flavin group , bromide , halide , stereochemistry , organic chemistry , enzyme , biochemistry , gene , alkyl , catalysis
Abstract Flavin‐dependent halogenases selectively introduce halogen substituents into (hetero‐)aromatic substrates and require only molecular oxygen and halide salts for this regioselective oxidative CH‐functionalization. Genomic analysis of Xanthomonas campestris pv. campestris B100 identified three novel putative members of this enzyme class. They were shown to introduce halogen substituents into, e. g., substituted indoles, while preferring bromide over chloride.