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Copper‐Catalyzed Intermolecular Hydroamination of Arylamines or Aza‐Heterocycles with Nitrostyrene Derivatives
Author(s) -
Park Subin,
Kang Seongil,
Lee Yunmi
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801582
Subject(s) - hydroamination , chemistry , intermolecular force , catalysis , reactivity (psychology) , copper , combinatorial chemistry , amine gas treating , carbene , organic chemistry , amination , markovnikov's rule , regioselectivity , molecule , medicine , alternative medicine , pathology
A new copper‐catalyzed protocol for the intermolecular anti‐Markovnikov addition of arylamines or heterocycles to terminal and unsymmetrical 1,2‐disubstituted vinylarenes has been developed. The direct hydroamination is catalyzed by a readily available N ‐heterocyclic carbene‐based copper complex and KO t ‐Bu, and the use of MeOH as an additive enhances the reactivity. The method provides a broad range of new and versatile amine compounds bearing various functional groups in good to excellent yields.