Premium
Dearomative [4+2] Cycloaddition of Oxindole‐Embedded ortho ‐Quinone Methides with 2,5‐Dialkylfurans
Author(s) -
Shen YaoBin,
Li ShuaiShuai,
Liu Xicheng,
Yu Liping,
Liu Qing,
Xiao Jian
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801509
Subject(s) - oxindole , chemistry , cycloaddition , quinone , combinatorial chemistry , reaction conditions , organic chemistry , medicinal chemistry , catalysis
2,5‐Dialkylfurans were facilely converted to pharmaceutically significant spiro[chroman‐4,3′‐oxindole] scaffolds via an organocatalytic dearomative [4+2] cycloaddition with oxindole‐embedded ortho ‐quinone methides. This method featured mild reaction conditions, simple operation, good yields, and excellent diastereoselectivities.