Premium
Rhodium(II)‐Catalyzed Formal [4+1]‐Cycloaddition of Pyridotriazoles and Propargyl Alcohols: Synthesis of 2,5‐Dihydrofurans
Author(s) -
Lv Xinxin,
Yang Haijian,
Shi Taoda,
Xing Dong,
Xu Xinfang,
Hu Wenhao
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801497
Subject(s) - chemistry , oxonium ion , propargyl , cycloaddition , rhodium , ylide , formal synthesis , catalysis , alkyne , aryl , medicinal chemistry , propargyl alcohol , organic chemistry , ion , alkyl
A rhodium‐catalyzed formal [4+1]‐cycloaddition of pyridotriazoles and aryl propargyl alcohols is reported, providing an effective access to 2‐pyridyl‐substituted 2,5‐dihydrofuran derivatives in moderate to high yields. Mechanistically, the proposed oxonium ylide intermediate in this catalytic alkyne carbocyclization transformation is verified by an interception experiment for the first time.