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Access to CF 3 ‐Containing Cyclopentaquinolinone Derivatives from Indolyl‐ynones via Silver‐Catalyzed One‐pot Reaction
Author(s) -
Han Guifang,
Xue Li,
Zhao Lili,
Zhu Tiaozhen,
Hou Jingli,
Song Yuguang,
Liu Yangping
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801482
Subject(s) - chemistry , indole test , reagent , dehydrogenation , catalysis , combinatorial chemistry , methylation , ring (chemistry) , reaction conditions , cascade , cascade reaction , organic chemistry , medicinal chemistry , biochemistry , chromatography , gene
An unexpected Ag(I)‐catalyzed cascade reaction between substituted indolyl‐ynone and Togni's reagent has been disclosed in which multiple processes occur including indole dearomatization, ring expansion, trifluoro‐methylation and dehydrogenation. This one‐pot reaction can be used to conveniently access diverse CF 3 ‐containing multisubstituted cyclopentaquinolinone scaffolds in moderate to good yields.