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2‐Alkynylaryl Aldehydes (Enynals) in Organic Synthesis
Author(s) -
Li Longlong,
Huang Dayun,
Shi Chengjin,
Yan Guobing
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801472
Subject(s) - chemistry , electrophile , malononitrile , organic chemistry , iodobenzene , hydrazine (antidepressant) , acetal , imine , aldehyde , organic synthesis , combinatorial chemistry , catalysis , chromatography
2‐Alkynylaryl aldehydes are widely used in organic reactions. Their great success is rooted in their multiple functional groups. This review will focus on five kinds of triggered mechanisms: (i) aldehydes as electrophiles, (ii) alkynes as electrophiles, (iii) 5‐ exo ‐ dig reactions, (iv) 6‐ endo ‐ dig intermediates, and (v) imine intermediates via 6‐ endo ‐ dig cyclizations. Reactions with alkenes, alkynes, arenes, malononitrile, alcohols, amines, amides, acetal, ketones, hydrazine, iodobenzene, azides, carbenes, arylboronic acids, amino acids etc. will be discussed. We hope that this review will pronote future research in this area.