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Synthesis of Tetrahydroisoindolinones via a Metal‐Free Dehydrogenative Diels‐Alder Reaction
Author(s) -
Xu WenLei,
Tang Lei,
Ge ChenYu,
Chen Jie,
Zhou Ling
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801436
Subject(s) - chemistry , diels–alder reaction , scope (computer science) , functional group , substrate (aquarium) , metal , combinatorial chemistry , reaction conditions , organic chemistry , catalysis , ecology , polymer , computer science , biology , programming language
A metal‐free dehydrogenative Diels‐Alder reaction of substituted alkenes for the synthesis of tetrahydroisoindolinones has been exploited for the first time. This new method features functional group tolerance and broad substrate scope, providing an efficient access to biologically active tetrahydroisoindolinone skeletons with endo steroselectivity in good to excellent yields.