Premium
Iridium‐Catalyzed Hydroxyl‐Enabled Cycloaddition of Azides and Alkynes
Author(s) -
Chen Renjie,
Zeng Linwei,
Lai Zhencheng,
Cui Sunliang
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801410
Subject(s) - cycloaddition , chemistry , iridium , regioselectivity , catalysis , combinatorial chemistry , group (periodic table) , organic chemistry
A novel iridium‐catalyzed hydroxyl‐enabled cycloaddition of azides and alkynes has been developed. In the presence of catalytic amount (2 mol%) of [Ir(cod)Cl] 2 , the 2‐alkynyl phenols would engage in a regioselective cycloaddition with various azides for rapid access to diverse triazoles, and the hydroxyl group acts as directing group to enable this reaction. The process is featured mild and biocompatible reaction condition with the achievement of brevity and diversity. Furthermore, the hydroxyl group offers ample opportunity for late‐stage divergent transformations of the products.