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Palladium Catalyzed Regioselective C4‐Arylation and Olefination of Indoles and Azaindoles
Author(s) -
Thrimurtulu Neetipalli,
Dey Arnab,
Singh Anurag,
Pal Kuntal,
Maiti Debabrata,
Volla Chandra M. R.
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801378
Subject(s) - regioselectivity , chemistry , indole test , palladium , catalysis , functional group , combinatorial chemistry , glycine , stereochemistry , organic chemistry , amino acid , biochemistry , polymer
A convergent strategy for the synthesis of biologically relevant C4‐substituted indole scaffolds was demonstrated using Pd(II)‐catalyzed remote C−H functionalization of indoles and azaindoles. The reaction displays high regioselectivity for the C4‐position of indole‐3‐carbaldehydes using glycine as an inexpensive transient directing group. Notable features of this transformation include the selective formation of six‐membered palladacyle and excellent functional group tolerance.