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Synthesis of Benzimidazoles through Palladium‐Catalyzed Amination of 2‐Iodobenzimines with Diaziridinone
Author(s) -
Ma Ding,
Ji Xiaoming,
Wu Zhuo,
Cheng Cang,
Zhou Bo,
Zhang Yanghui
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801367
Subject(s) - chemistry , amination , palladium , catalysis , aryl , combinatorial chemistry , organic chemistry , alkyl
An efficient approach for the synthesis of benzimidazoles has been developed through the Pd‐catalyzed amination of 2‐iodobenzimines with diaziridinone. A wide range of 2‐(hetero)aryl benzimidazloes are synthesized in good to excellent yields. The reactions likely involve C , C ‐palladacycles derived from 2‐iodobenzimines as the key intermediate, and the palladacycles reacted with diaziridinone to form benzimidazoles.