A Simple Transformation of 1‐(Isoxazol‐3‐yl)ureas to 5‐(2‐oxoalkyl)‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones through Base‐Promoted Boulton‐Katritzky Rearrangement | Zendy

Liu Jisheng | Zendy; Chen Chen | Zendy; Kotagiri Rajendraprasad | Zendy; Yang Wenqiang | Zendy; Cai Qian | Zendy

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A Simple Transformation of 1‐(Isoxazol‐3‐yl)ureas to 5‐(2‐oxoalkyl)‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones through Base‐Promoted Boulton‐Katritzky Rearrangement

Author(s) -

Liu Jisheng,

Chen Chen,

Kotagiri Rajendraprasad,

Yang Wenqiang,

Cai Qian

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801357

Subject(s) - chemistry , base (topology) , simple (philosophy) , transformation (genetics) , computational chemistry , combinatorial chemistry , stereochemistry , biochemistry , mathematics , mathematical analysis , philosophy , epistemology , gene

2,4‐Dihydro‐ 3H ‐1,2,4‐triazol‐3‐ones are a class of biologically important heterocycles. A novel and simple synthesis of such structures is developed. The method is through a base‐promoted Boulton‐Katritzky‐type rearrangement of 1‐(isoxazol‐3‐yl)ureas and is highly efficient for the formation of 2,4‐dihydro‐ 3H ‐1,2,4‐triazol‐3‐ones.

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