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A Simple Transformation of 1‐(Isoxazol‐3‐yl)ureas to 5‐(2‐oxoalkyl)‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones through Base‐Promoted Boulton‐Katritzky Rearrangement
Author(s) -
Liu Jisheng,
Chen Chen,
Kotagiri Rajendraprasad,
Yang Wenqiang,
Cai Qian
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801357
Subject(s) - chemistry , base (topology) , simple (philosophy) , transformation (genetics) , computational chemistry , combinatorial chemistry , stereochemistry , biochemistry , mathematics , mathematical analysis , philosophy , epistemology , gene
2,4‐Dihydro‐ 3H ‐1,2,4‐triazol‐3‐ones are a class of biologically important heterocycles. A novel and simple synthesis of such structures is developed. The method is through a base‐promoted Boulton‐Katritzky‐type rearrangement of 1‐(isoxazol‐3‐yl)ureas and is highly efficient for the formation of 2,4‐dihydro‐ 3H ‐1,2,4‐triazol‐3‐ones.