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Chemo‐selective Rh(II)/Pd(0) Dual Catalysis: Synthesis of All‐Carbon C3‐Quaternary Allylic Oxindoles from N ‐Aryl‐ α ‐Diazo‐ β ‐Keto‐Amides with Functionalized Allyl Carbonates
Author(s) -
Chen LingHang,
Ma YangTing,
Yang Fang,
Huang XiaoYan,
Chen ShuWei,
Ji Kegong,
Chen ZiSheng
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801346
Subject(s) - chemistry , diazo , tsuji–trost reaction , allylic rearrangement , aryl , catalysis , medicinal chemistry , intramolecular force , combinatorial chemistry , cascade reaction , alkylation , organic chemistry , alkyl
A chemo‐selective Rh(II)/Pd(0) dual catalysis that promotes one‐pot synthesis of C3‐quaternary allylic oxindoles from N ‐aryl‐ α ‐diazo‐ β ‐ketoamides and functionalized allyl carbonates in good to excellent yields has been developed. The efficiency of this transformation relies on the choice of Rh(II)/Pd(0) dual catalysis strategy that enabled cascade intramolecular aryl C−H insertion and allylic alkylation under mild conditions.