Chemo‐selective Rh(II)/Pd(0) Dual Catalysis: Synthesis of All‐Carbon C3‐Quaternary Allylic Oxindoles from  N ‐Aryl‐ α ‐Diazo‐ β ‐Keto‐Amides with Functionalized Allyl Carbonates | Zendy

Chen LingHang | Zendy; Ma YangTing | Zendy; Yang Fang | Zendy; Huang XiaoYan | Zendy; Chen ShuWei | Zendy; Ji Kegong | Zendy; Chen ZiSheng | Zendy

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Chemo‐selective Rh(II)/Pd(0) Dual Catalysis: Synthesis of All‐Carbon C3‐Quaternary Allylic Oxindoles from N ‐Aryl‐ α ‐Diazo‐ β ‐Keto‐Amides with Functionalized Allyl Carbonates

Author(s) -

Chen LingHang,

Ma YangTing,

Yang Fang,

Huang XiaoYan,

Chen ShuWei,

Ji Kegong,

Chen ZiSheng

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801346

Subject(s) - chemistry , diazo , tsuji–trost reaction , allylic rearrangement , aryl , catalysis , medicinal chemistry , intramolecular force , combinatorial chemistry , cascade reaction , alkylation , organic chemistry , alkyl

A chemo‐selective Rh(II)/Pd(0) dual catalysis that promotes one‐pot synthesis of C3‐quaternary allylic oxindoles from N ‐aryl‐ α ‐diazo‐ β ‐ketoamides and functionalized allyl carbonates in good to excellent yields has been developed. The efficiency of this transformation relies on the choice of Rh(II)/Pd(0) dual catalysis strategy that enabled cascade intramolecular aryl C−H insertion and allylic alkylation under mild conditions.

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