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Aerobic α‐Oxidation of N ‐Substituted Tetrahydroisoquinolines to Dihydroisoquinolones via Organo‐photocatalysis
Author(s) -
Aganda Kim Christopher C.,
Hong Boseok,
Lee Anna
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801301
Subject(s) - chemistry , photocatalysis , eosin y , yield (engineering) , oxygen , photochemistry , atmosphere (unit) , visible spectrum , molecular oxygen , organic chemistry , catalysis , materials science , physics , optoelectronics , metallurgy , thermodynamics
An efficient visible‐light‐induced α‐oxidation of N ‐substituted tetrahydroisoquinolines to dihydroisoquinolones has been developed using eosin Y as an organo‐photocatalyst and oxygen as a green oxidant. The reactions were carried out under mild reaction conditions; the desired dihydroisoquinolones were obtained in up to 96% yield at room temperature under oxygen atmosphere. This transformation provides a convenient route to dihydroisoquinolones with a wide range of substrates.