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Ligand‐Free Iridium‐Catalyzed Dehydrogenative ortho C−H Borylation of Benzyl‐2‐Pyridines at Room Temperature
Author(s) -
Yang Yuhuan,
Gao Qian,
Xu Senmiao
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801292
Subject(s) - borylation , chemistry , iridium , reagent , catalysis , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , photochemistry , organic chemistry , aryl , receptor , biochemistry , alkyl
A convenient and ligand‐free iridium‐catalyzed dehydrogenative ortho C−H borylation of benzyl‐2‐pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)] 2 . The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities.