Synthesis of 4‐Alkenyl Benzoxazoles via Pd‐catalyzed  ortho  C−H Functionalization of 2‐Amidophenols | Zendy

Panda Niranjan | Zendy; Sahoo Kanchanbala | Zendy

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Synthesis of 4‐Alkenyl Benzoxazoles via Pd‐catalyzed ortho C−H Functionalization of 2‐Amidophenols

Author(s) -

Panda Niranjan,

Sahoo Kanchanbala

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801272

Subject(s) - chemistry , annulation , regioselectivity , intramolecular force , catalysis , alkene , olefin fiber , surface modification , tandem , aryl , combinatorial chemistry , palladium , medicinal chemistry , stereochemistry , organic chemistry , materials science , alkyl , composite material

A one‐pot direct transformation to remotely C−H alkene functionalized 2‐aryl benzoxazoles from the reaction of amidophenol and electronically deficient olefin was reported. Control experiments confirm that the Pd‐catalyzed regioselective C−H activation/alkenylation occurs at the first step by leading to ortho ‐alkenylated amidophenol; which subsequently underwent tandem intramolecular annulation to afford C4‐alkenylated 2‐arylbenzoxazole derivatives.

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