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Atroposelective Synthesis of PINAP via Dynamic Kinetic Asymmetric Transformation
Author(s) -
Han SeoJung,
Bhat Vikram,
Stoltz Brian M.,
Virgil Scott C.
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801248
Subject(s) - chemistry , kinetic resolution , catalysis , combinatorial chemistry , palladium , transformation (genetics) , enantiomer , enantioselective synthesis , enantiomeric excess , organic chemistry , biochemistry , gene
Abstract The atroposelective synthesis of PINAP ligands has been accomplished via a palladium‐catalyzed C−P coupling process through dynamic kinetic asymmetric transformation. These catalytic conditions allow access to a wide variety of alkoxy‐ and benzyloxy‐substituted PINAP ligands in high enantiomeric excess. The methods described in this communication afford valuable P,N ligands in good yields and high enantioselectivity using low catalyst loading.