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Cadmium Sulfide Quantum‐Dot‐Photocatalyzed Cascade Cyclization of Functionalized Difluoromethyl Chlorides with Unactivated Olefins
Author(s) -
Hu Jinglin,
Pu TongJun,
Xu ZhuoWei,
Xu WenYi,
Feng YiSi
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801246
Subject(s) - chemistry , cadmium sulfide , cascade , sulfide , cleavage (geology) , cadmium , quantum dot , combinatorial chemistry , medicinal chemistry , photochemistry , organic chemistry , inorganic chemistry , nanotechnology , materials science , geotechnical engineering , chromatography , fracture (geology) , engineering
A cadmium sulfide quantum‐dot‐photocatalyzed C( sp 3 )−Cl bond cleavage of ethyl chlorodifluoroacetate and cascade cyclization with unactivated olefins is described herein. This reaction provides a cost‐efficient method for synthesizing a wide range of CF 2 ‐containing azaheterocycles from a variety of functionalized difluoromethyl chlorides. Furthermore, the results of a preliminary anti‐proliferative activity study indicate an in vitro anti‐proliferative activity superior to that of doxorubicin with IC 50 values of 1.140 μM on triple negative breast cancer (MDA‐MB‐231) and 2.129 μM on lung (A549) carcinoma cells.