z-logo
Premium
A Copper (II) Acetate Mediated Oxidative‐Coupling of Styrenes and Ethers Through an Unactivated C( sp 3 )−H Bond Functionalization
Author(s) -
Yan Zhan,
Wang NaiXing,
Gao XueWang,
Li JianLi,
Wu YueHua,
Zhang Tong,
Chen ShiLu,
Xing Yalan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801243
Subject(s) - chemistry , regioselectivity , surface modification , oxidative coupling of methane , copper , functional group , radical , oxidative phosphorylation , reaction mechanism , medicinal chemistry , organic chemistry , polymer chemistry , photochemistry , combinatorial chemistry , catalysis , polymer , biochemistry
A Copper (II) Acetate Mediated Oxidative Coupling of Styrenes and Ethers Through an Unactivated C( sp 3 )−H Bond Functionalization A functionalization of unactivated C( sp 3 )‐H bond of ethers with styrenes was described. This C−C bond formation has been developed using t ‐butyl hydroperoxide (TBHP) as a radical initiator and DBU as an additive agent. Typical ethers underwent a free‐radical addition of styrenes to give direct difunctionalization products with excellent regioselectivity and efficiency. This reaction features good yields and functional group compatibility with simple operation and mild conditions. A plausible reaction mechanism has been proposed. DFT simulation and theory calculation also provided important evidence for the proposed free‐radical mechanism.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here