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Copper‐Catalyzed Regioselective Oxidative Cycloamidation of α ‐[( β ‐Dimethylamino)propenoyl]‐Alkylamides: Synthetic Route to Substituted Pyrrolidine‐2,4‐diones
Author(s) -
Yuan Jingwen,
Rao Chitturi Bhujanga,
Liang Yongjiu,
Zhang Rui,
Zhang Qian,
Hou Liman,
Dong Dewen
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801237
Subject(s) - chemistry , regioselectivity , pyrrolidine , intramolecular force , catalysis , bromide , combinatorial chemistry , oxidative phosphorylation , organic chemistry , medicinal chemistry , biochemistry
An intramolecular oxidative amidation of varied α ‐[( β ‐dimethylamino)propenoyl]‐alkylamides catalyzed by copper(II) bromide in the presence of PIFA and TFA has been described. This process features mild reaction conditions, simple execution, good yields, high regioselectivity, and thereby, provides not only a facile and efficient protocol for the construction of C−N bond, but also a straightforward synthetic route to densely substituted pyrrolidine‐2,4‐diones.