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Potassium Persulfate‐Mediated Thiocyanation of 2 H ‐Indazole under Iron‐Catalysis
Author(s) -
Dey Amrita,
Hajra Alakananda
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801232
Subject(s) - chemistry , potassium persulfate , indazole , potassium thiocyanate , ammonium thiocyanate , ammonium persulfate , catalysis , aryl , persulfate , medicinal chemistry , organic chemistry , alkyl , polymerization , polymer
Abstract Potassium persulfate‐mediated thiocyanation of 2 H ‐indazoles has been developed using ammonium thiocyanate as thiocyanating agent under iron‐catalysis at room temperature. 2‐Aryl‐3‐thiocyanato‐2 H ‐indazoles are synthesized in good yields with a broad substrates scope. This methodology is also applicable for the selenocyanation of 2 H ‐indazoles. The mechanistic study suggests the reaction probably proceeds through a radical pathway.