Domino Reactions Initiated by Copper‐Catalyzed Aryl‐I Bond Thiolation For the Switchable Synthesis of 2,3‐Dihydrobenzothiazinones and Benzoisothiazolones | Zendy

Xiong Jin | Zendy; Zhong Guofeng | Zendy; Liu Yunyun | Zendy

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Domino Reactions Initiated by Copper‐Catalyzed Aryl‐I Bond Thiolation For the Switchable Synthesis of 2,3‐Dihydrobenzothiazinones and Benzoisothiazolones

Author(s) -

Xiong Jin,

Zhong Guofeng,

Liu Yunyun

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801221

Subject(s) - chemistry , aryl , copper , domino , sulfur , catalysis , dichloromethane , ring (chemistry) , microwave irradiation , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , solvent , alkyl

The three‐component reactions of o ‐iodobenzamides, elemental sulfur and dichloromethane (DCM) providing 2,3‐dihydro‐4 H ‐benzo[e][1,3]thiazin‐4‐ones (2,3‐dihydrobenzothiazinones) are accomplished via copper‐catalyzed aryl C−I thiolation and subsequent N ‐, S ‐hetero ring formation. In addition, the in situ aryl C−I bond thiolation is also employed for the switchable synthesis of benzo[d]isothiazol‐3(2 H )‐ones (benzoisothiazolones) by subjecting o ‐iodobenzamides, elemental sulfur to the copper‐catalyzed condition with microwave irradiation.

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