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Cover Picture: MOFs Extend the Lifetime of Pd(II) Catalyst for Room Temperature Alkenylation of Enamine‐Like Arenes (Adv. Synth. Catal. 20/2018)
Author(s) -
Cirujano Francisco G.,
Leo Pedro,
Vercammen Jannick,
Smolders Simon,
Orcajo Gisela,
De Vos Dirk E.
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801220
Subject(s) - chemistry , catalysis , microporous material , redox , enamine , cationic polymerization , medicinal chemistry , combinatorial chemistry , organic chemistry
The inside cover picture , provided by Cirujano and co‐workers, illustrates the results of their work on recycling catalytic amounts of Pd(OAc) 2 in the presence of redox active, stable and reusable metal‐organic microporous frameworks (MOF‐74), thus achieving the C−H functionalization of pharmaceutically interesting aza‐heterocycles with alkenes. This is the first time that redox/acid active sites in the porous, non‐toxic and earth abundant robust MOF‐74 platform are used to avoid the fast deactivation of the cationic Pd species during the room temperature and ambient pressure alkenylation of indoles and uracils under batch and continuous flow conditions. Details can be found in the communication on pages 3872–3876 (F. G. Cirujano, P. Leo, J. Vercammen, S. Smolders, G. Orcajo, D. E. De Vos, Adv. Synth. Catal . 2018 , 360 , 3872–3876; DOI: 10.1002/adsc.201800817)