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Rhodium‐Catalyzed Cascade Annulation Reaction via C−H Activation of Azobenzenes with Terminal Alkynes: A Synthesis of Indolo[1,2‐ b ]cinnolines
Author(s) -
Zhang Shuwei,
Wang Biying,
Jia Xiaodong,
Yuan Yu
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801183
Subject(s) - annulation , chemistry , rhodium , catalysis , cascade , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , chromatography
The approach for direct synthesis of Indolo[1,2‐ b ]cinnolines was first developed from azobenzenes and terminal alkynes by rhodium‐catalyzed cascade annulation reaction. In this reaction, the C−C and C−N bonds can be simultaneously constructed via C−H activation to afford the desired products in moderate to good yields.
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