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Transition‐Metal Free Construction of Isoquinoline‐fused Triazines Containing Alkenyl C−X Bonds
Author(s) -
Cheng Xiao,
Cao Xia,
Zhou ShuangJing,
Cai BaoGui,
He XiangKui,
Xuan Jun
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801181
Subject(s) - isoquinoline , chemistry , cycloaddition , transition metal , functional group , halogen , substrate (aquarium) , stereochemistry , combinatorial chemistry , polymer chemistry , organic chemistry , catalysis , polymer , alkyl , oceanography , geology
A halogen and base‐mediated [3+3]‐cycloaddition reaction of in situ generated azaoxyallyl cations with in situ formed C,N‐cyclic azomethine imines is reported. This one‐pot transition metal‐free cycloaddition process exhibits broad substrate scope, excellent functional group tolerance, and affords a series of biologically important isoquinoline‐fused triazines in good to excellent yields, which containing valuable alkenyl C−X bonds (X=Br, I).