Asymmetric Phosphine‐Catalyzed [4+1] Annulations of  o ‐Quinone Methides with MBH Carbonates | Zendy

Zhou Tao | Zendy; Xia Tong | Zendy; Liu Zhenli | Zendy; Liu Lu | Zendy; Zhang Junliang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Asymmetric Phosphine‐Catalyzed [4+1] Annulations of o ‐Quinone Methides with MBH Carbonates

Author(s) -

Zhou Tao,

Xia Tong,

Liu Zhenli,

Liu Lu,

Zhang Junliang

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801152

Subject(s) - chemistry , phosphine , enantioselective synthesis , annulation , catalysis , quinone , combinatorial chemistry , organic chemistry , organocatalysis

Chiral dihydrobenzofuran units are frequently present in molecules with significant biological and pharmaceutical activities. Herein, we present the first enantioselective formal [4+1] annulation of Morita‐Baylis‐Hillman carbonates with o ‐quinone methides ( o ‐QMs) catalyzed by a newly designed chiral phosphine catalyst. Under the mild and eco‐friendly conditions, a wide range of polysubstituted dihydrobenzofurans were obtained in good yields with excellent enantioselectivities.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research