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Enantioseletive Fluorination of 3‐Functionalized Oxindoles Using Electron‐rich Amino Urea Catalyst
Author(s) -
Jiang Xiaojian,
Wang Haitao,
He Haoquan,
Wang Wei,
Wang Yuqiang,
Ke Zhihai,
Yeung YingYeung
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801133
Subject(s) - chemistry , oxindole , nitrile , catalysis , enantioselective synthesis , urea , selectivity , methylene , organic chemistry , combinatorial chemistry
An enantioselective fluorination of 3‐functionalized oxindoles using electron‐rich amino urea catalyst is described. Various 3‐functionalized 3‐fluoro‐2‐oxindoles were obtained in good yields and enantio‐selectivity. The resulting enantioenriched 3‐methylene nitrile 3‐fluoro‐2‐oxindole product was found to inhibit indoleamine 2,3‐dioxygenase considerably.