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[3+2] Cyclization of Azidotrimethylsilane with Quinoxalin‐2(1 H )‐Ones to Synthesize Tetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐Ones
Author(s) -
Yang Qiming,
Zhang Yuecheng,
Sun Qian,
Shang Kun,
Zhang HongYu,
Zhao Jiquan
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801076
Subject(s) - chemistry , combinatorial chemistry , protocol (science) , medicinal chemistry , stereochemistry , medicine , pathology , alternative medicine
A convenient and efficient protocol for the synthesis of thetetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐ones via copper‐catalyzed [3+2] cyclization of azidotrimethylsilane with quinoxalin‐2(1 H )‐ones under mild conditions has been disclosed. This practical protocol is compatible with a variety of functional groups and provides an access to functionalized tetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐ones from readily available and safe starting materials.