[3+2] Cyclization of Azidotrimethylsilane with Quinoxalin‐2(1 H )‐Ones to Synthesize Tetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐Ones | Zendy

Yang Qiming | Zendy; Zhang Yuecheng | Zendy; Sun Qian | Zendy; Shang Kun | Zendy; Zhang HongYu | Zendy; Zhao Jiquan | Zendy

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[3+2] Cyclization of Azidotrimethylsilane with Quinoxalin‐2(1 H )‐Ones to Synthesize Tetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐Ones

Author(s) -

Yang Qiming,

Zhang Yuecheng,

Sun Qian,

Shang Kun,

Zhang HongYu,

Zhao Jiquan

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801076

Subject(s) - chemistry , combinatorial chemistry , protocol (science) , medicinal chemistry , stereochemistry , medicine , pathology , alternative medicine

A convenient and efficient protocol for the synthesis of thetetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐ones via copper‐catalyzed [3+2] cyclization of azidotrimethylsilane with quinoxalin‐2(1 H )‐ones under mild conditions has been disclosed. This practical protocol is compatible with a variety of functional groups and provides an access to functionalized tetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐ones from readily available and safe starting materials.

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