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Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes
Author(s) -
Pan GaoFei,
Zhu XueQing,
Guo RuiLi,
Gao YaRu,
Wang YongQiang
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801058
Subject(s) - dehydrogenation , chemistry , catalysis , combinatorial chemistry , compatibility (geochemistry) , substrate (aquarium) , organic chemistry , palladium , scope (computer science) , chemical engineering , geology , oceanography , computer science , engineering , programming language
Abstract A general, efficient and economic palladium‐catalyzed dehydrogenation to form enones or enals has been developed. The approach possesses extremely broad substrate scope including various linear or cyclic saturated ketones and aldehydes. The protocol is ligand‐free, and molecular oxygen is used as the sole clean oxidant in the reaction. Due to mild reaction conditions, good functional group compatibility, and versatile utilities of enones and enals, the method can be applied in the late‐stage synthesis of natural products, pharmaceuticals and fine chemicals.