Organocatalytic Asymmetric Domino Michael/Acyl Transfer Reaction Between  α ‐Nitroketones and  in situ‐ Generated  ortho ‐Quinone Methides: Route to 2‐(1‐Arylethyl)phenols | Zendy

Gharui Chandan | Zendy; Behera Debasmita | Zendy; Pan Subhas Chandra | Zendy

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Organocatalytic Asymmetric Domino Michael/Acyl Transfer Reaction Between α ‐Nitroketones and in situ‐ Generated ortho ‐Quinone Methides: Route to 2‐(1‐Arylethyl)phenols

Author(s) -

Gharui Chandan,

Behera Debasmita,

Pan Subhas Chandra

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201801015

Subject(s) - bifunctional , chemistry , squaramide , domino , quinone , phenols , michael reaction , catalysis , organocatalysis , cascade reaction , in situ , organic chemistry , enantioselective synthesis

An organocatalytic asymmetric domino Michael/acyl transfer reaction between α ‐nitroketones and o ‐quinone methides is disclosed. o ‐Quinone methides are generated in situ from 2‐sulfonylmethylphenols in basic medium. With 10 mol% of bifunctional squaramide catalyst, high yields and excellent enantioselectivities are achieved for a variety of O‐acyl 2‐(1‐arylethyl)phenols under mild reaction condition.

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