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Organocatalytic Asymmetric Domino Michael/Acyl Transfer Reaction Between α ‐Nitroketones and in situ‐ Generated ortho ‐Quinone Methides: Route to 2‐(1‐Arylethyl)phenols
Author(s) -
Gharui Chandan,
Behera Debasmita,
Pan Subhas Chandra
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201801015
Subject(s) - bifunctional , chemistry , squaramide , domino , quinone , phenols , michael reaction , catalysis , organocatalysis , cascade reaction , in situ , organic chemistry , enantioselective synthesis
An organocatalytic asymmetric domino Michael/acyl transfer reaction between α ‐nitroketones and o ‐quinone methides is disclosed. o ‐Quinone methides are generated in situ from 2‐sulfonylmethylphenols in basic medium. With 10 mol% of bifunctional squaramide catalyst, high yields and excellent enantioselectivities are achieved for a variety of O‐acyl 2‐(1‐arylethyl)phenols under mild reaction condition.