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Visible‐Light Photoredox‐Catalyzed Thioacetalization of Aldehydes Under Metal‐Free and Solvent‐Free Conditions
Author(s) -
Du Kai,
Wang ShaoChien,
Basha R. Sidick,
Lee ChinFa
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800999
Subject(s) - chemistry , photoredox catalysis , photochemistry , catalysis , visible spectrum , thiol , radical , solvent , metal , photocatalysis , organic chemistry , physics , optoelectronics
A first visible‐light photoredox‐catalyzed thioacetalization of aldehydes under metal‐free and solvent‐free conditions is described. Under blue LED irradiation, a reactive thiyl radical was initially generated through single‐electron oxidation of thiol, which subsequently reacted with aldehydes to afford dithioacetals following a radical mechanism. The reaction proceeded under ambient conditions, and a wide range of acyclic and cyclic dithioacetal derivatives were afforded in good to excellent yields.