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Electrochemical Dehydrogenative Cross‐Coupling of Quinoxalin‐2(1 H )‐ones with Amines for the Synthesis of 3‐Aminoquinoxalinones
Author(s) -
Li KeJing,
Xu Kun,
Liu YongGuo,
Zeng ChengChu,
Sun BaoGuo
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800989
Subject(s) - chemistry , amination , electrochemistry , yield (engineering) , combinatorial chemistry , electrolyte , reductive amination , coupling (piping) , organic chemistry , electrode , catalysis , materials science , metallurgy , mechanical engineering , engineering
An efficient protocol for the synthesis of 3‐aminoquinoxalinones via the electrochemical dehydrogenative C‐3 amination of quinoxalin‐2(1 H )‐ones was developed. With aliphatic amines and azoles as the nitrogen sources, a series of 3‐aminoquinoxalinones was obtained in up to 99% yield. This direct electrolytic method avoids the use of transition metals and external oxidants, and represents an appealing alternative for the synthesis of 3‐aminoquinoxalinones.