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Nickel‐Catalyzed Denitrogenative ortho ‐Arylation of Benzotriazinones with Organic Boronic Acids: an Efficient Route to Losartan and Irbesartan Drug Molecules
Author(s) -
Thorat Vijaykumar H.,
Upadhyay Nitinkumar Satyadev,
Cheng ChienHong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800923
Subject(s) - chemistry , losartan , catalysis , combinatorial chemistry , nickel , irbesartan , molecule , organic chemistry , medicinal chemistry , angiotensin ii , receptor , biochemistry , medicine , alternative medicine , pathology
Denitrogenative ortho ‐arylation, vinylation and methylation of 1,2,3‐benzotriazin‐4‐(3 H )‐ones with organic boronic acids catalyzed by nickel complexes to give a wide range of o‐ substituted benzamides were demonstrated. Further, the catalytic reaction is successfully applied to the synthesis of the popular hypertensive drugs losartan and irbesartan in high yields.