Premium
Copper(II) Acetate‐Catalyzed Synthesis of Phosphorylated Pyridines via Denitrogenative C−P Coupling between Pyridotriazoles and P(O)H Compounds
Author(s) -
Shen Ruwei,
Dong Chao,
Yang Jianlin,
Han LiBiao
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800909
Subject(s) - chemistry , copper , catalysis , carbene , coupling reaction , reaction conditions , medicinal chemistry , coupling (piping) , combinatorial chemistry , in situ , stereochemistry , organic chemistry , mechanical engineering , engineering
A new inexpensive copper‐catalyzed denitrogenative C−P coupling reaction of pyridotriazoles with P(O)H compounds has been developed. The reaction proceeds via a process of copper‐catalyzed P(O)−H insertion into the pyridyl carbene intermediates generated in situ from pyridotriazoles. This reaction provides a new and effective method for the synthesis of a variety of 2‐picolylphosphoryl compounds.