Copper(II) Acetate‐Catalyzed Synthesis of Phosphorylated Pyridines  via  Denitrogenative C−P Coupling between Pyridotriazoles and P(O)H Compounds | Zendy

Shen Ruwei | Zendy; Dong Chao | Zendy; Yang Jianlin | Zendy; Han LiBiao | Zendy

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Copper(II) Acetate‐Catalyzed Synthesis of Phosphorylated Pyridines via Denitrogenative C−P Coupling between Pyridotriazoles and P(O)H Compounds

Author(s) -

Shen Ruwei,

Dong Chao,

Yang Jianlin,

Han LiBiao

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800909

Subject(s) - chemistry , copper , catalysis , carbene , coupling reaction , reaction conditions , medicinal chemistry , coupling (piping) , combinatorial chemistry , in situ , stereochemistry , organic chemistry , mechanical engineering , engineering

A new inexpensive copper‐catalyzed denitrogenative C−P coupling reaction of pyridotriazoles with P(O)H compounds has been developed. The reaction proceeds via a process of copper‐catalyzed P(O)−H insertion into the pyridyl carbene intermediates generated in situ from pyridotriazoles. This reaction provides a new and effective method for the synthesis of a variety of 2‐picolylphosphoryl compounds.

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