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Chiral N , N ′‐Dioxide/Scandium(III)‐Catalyzed Asymmetric Alkylation of N ‐Unprotected 3‐Substituted Oxindoles
Author(s) -
He Changqiang,
Cao Weidi,
Zhang Jianlin,
Ge Shulin,
Feng Xiaoming
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800877
Subject(s) - chemistry , stereocenter , scandium , enantioselective synthesis , alkylation , catalysis , yield (engineering) , medicinal chemistry , organic chemistry , materials science , metallurgy
An efficient enantioselective alkylation of N ‐unprotected 3‐substituted oxindoles was realized by using a chiral N , N ′‐dioxide/scandium(III) complex as the catalyst. A wide range of 3,3‐dialkyl substituted oxindoles with quaternary stereocenters were obtained in high yields and ee values (up to 98% yield and 99% ee ).
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