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Copper‐Catalyzed Defluorinative Thioannulation of Trifluoropropynes for the Synthesis of 1,2‐Dithiole‐3‐thiones
Author(s) -
Wei Feng,
Shen XiaoQin,
Zhang XiaoHong,
Zhang XingGuo
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800846
Subject(s) - chemistry , sulfur , functional group , catalysis , copper , scope (computer science) , substrate (aquarium) , cleavage (geology) , bond cleavage , combinatorial chemistry , organic chemistry , oceanography , geotechnical engineering , fracture (geology) , computer science , engineering , programming language , geology , polymer
A simple and practical strategy for the preparation of 1,2‐dithiole‐3‐thiones via copper‐catalyzed defluorinative thioannulation of trifluoropropynes has been developed using elemental sulfur as the sole sulfur source. This reaction displays a wide substrate scope and high functional group tolerance to afford the corresponding S‐heterocycles in moderate to good yields and features efficient construction of multiple C−S bonds through C−F bond cleavage of CF 3 groups.
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