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Ruthenium (II)‐Catalyzed Oxidant‐Free Coupling/Cyclization of Benzimidates and Sulfoxonium Ylides to Form Substituted Isoquinolines
Author(s) -
Shi Xinxia,
Wang Rongchao,
Zeng Xiaofei,
Zhang Yilan,
Hu Huiling,
Xie Chunsong,
Wang Min
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800844
Subject(s) - chemistry , isoquinoline , ruthenium , annulation , catalysis , cascade , combinatorial chemistry , surface modification , alkynylation , organic chemistry , chromatography
Abstract A ruthenium‐catalyzed direct mono‐C−H functionalization/annulation cascade reaction of benzimidates and sulfoxonium ylides has been developed. The reaction proceeds smoothly with a broad range of substrates, giving access to a variety of isoquinoline derivatives in moderate to good yields using an organic acid additive under oxidant free conditions.