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Bioinspired Deamination of α ‐Amino Acid Derivatives Catalyzed by a Palladium/Nickel Complex
Author(s) -
Deng Gongtao,
Chen Jie,
Sun Wangbin,
Bian Kehan,
Jiang Yaojia,
Loh TeckPeng
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800823
Subject(s) - palladium , chemistry , deamination , catalysis , nickel , inert , transition metal , combinatorial chemistry , metal , inert gas , organic chemistry , enzyme
An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β ‐unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in‐easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium‐catalyzed inert sp 3 C−H activation as one of the key steps.