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MOFs Extend the Lifetime of Pd(II) Catalyst for Room Temperature Alkenylation of Enamine‐Like Arenes
Author(s) -
Cirujano Francisco G.,
Leo Pedro,
Vercammen Jannick,
Smolders Simon,
Orcajo Gisela,
De Vos Dirk E.
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800817
Subject(s) - chemistry , enamine , catalysis , microporous material , cationic polymerization , redox , combinatorial chemistry , metal organic framework , organic chemistry , polymer chemistry , photochemistry , adsorption
The synthesis of pharmaceutically relevant scaffolds, such as substituted indoles or uracils, through the alkenylation of the “enamine‐like” aromatic C−H bond is performed at room temperature using catalytic amounts of Pd(OAc) 2 in the presence of redox active, stable and reusable metal‐organic microporous frameworks. This is the first time that redox/acid active sites in the porous, non‐toxic and earth abundant robust MOF‐74 platform are used to avoid the fast deactivation of the cationic Pd species working under ambient conditions.